63341 Homes for Sale

63341 Homes for Sale

Welcome to the charming community of Defiance, nestled in the heart of St. Charles County, Missouri, with the vibrant zip code 63341. Known for its picturesque landscapes and a close-knit atmosphere, Defiance is a hidden gem that offers a perfect blend of rural serenity and modern conveniences.

This delightful area boasts a rich history and a strong sense of community, making it an ideal place for families, retirees, and anyone looking to escape the hustle and bustle of city life. Surrounded by scenic vineyards and lush rolling hills, Defiance provides a stunning backdrop for outdoor enthusiasts and wine lovers alike. With numerous parks and trails, residents can enjoy hiking, biking, and exploring the natural beauty that this region has to offer.

When it comes to real estate, Defiance has an impressive selection of homes for sale that cater to diverse tastes and budgets. Whether you're seeking a charming historic farmhouse, a contemporary family home, or a serene retreat on sprawling acreage, you’re sure to find your dream property in this enchanting area. The local real estate market is thriving, offering opportunities for both first-time buyers and seasoned investors.

Living in Defiance means enjoying a peaceful lifestyle while still being just a short drive away from the vibrant amenities of nearby cities. With excellent schools, friendly neighbors, and a strong community spirit, 63341 is more than just a zip code—it’s a place where you can truly feel at home. Come explore the possibilities and discover why so many are choosing to call Defiance, Missouri, their home!

Newest 63341 Homes for Sale

$1
3 Beds ⋅ 4 Baths ⋅ 26046445 MLS ⋅ ACTIVE Status
Improvements include a 2090 sq. ft. ranch home built in 1980. The home features 3 bedrooms, 2 full baths & 2 half baths, custom kitchen/breakfast room w/updated stainless steel appliances & granite marble top center island & counter tops, great room w/woodburning stone fireplace, wood floors, formal dining room, formal entry, main floor laundry, huge master bedroom w/large master bath w/tub & walk in shower & central vac. The home is total electric w/a metal roof, updated FA furnace & air, on septic that’s updated to St. Charles County code & public water. The home has an attached 2 car garage & large patio composite decking on west side of home. Other improvements include a 18’x24’ metal shop w/concrete floor, electric & 2 overhead doors w/insulated ceiling. A real nice building. Private, not shared 1½ acre stocked lake, park like setting. Restrictions of no hogs, other livestock allowed, no HOA Fees, Francis Howell R-III School District. This home to be sold at public auction on Saturday, August 29, 2026, there will be a public open house on Wednesday, August 5, 2026 and Wednesday, August 19, 2026 from 5:00 P.M. - 7:00 P.M.

1 Country Life, Defiance
$620,000
4 Beds ⋅ 4 Baths ⋅ 26045108 MLS ⋅ ACTIVE Status
Escape to your own private retreat with this stunning log home nestled on 3 picturesque acres, where peaceful country living meets modern comfort. Surrounded by mature trees and breathtaking natural beauty, you'll enjoy the serenity of nature while remaining just 15 minutes from Highway 40, offering the perfect balance of privacy and convenience. Enjoy the view from either the fully covered front deck or fully covered back deck! Inside, this spacious 4-bedroom, 3.5-bath home welcomes you with a dramatic two-story great room, soaring ceilings, a striking floor-to-ceiling stone fireplace, and an open loft overlooking the living space below. Warm bamboo flooring flows throughout the main level, complementing the rustic charm with updated finishes. The beautifully renovated kitchen is the heart of the home, featuring quartz countertops, 42-inch cabinetry, a custom tile backsplash, and updated appliances, making it as functional as it is beautiful. The thoughtfully redesigned floor plan includes a convenient main-floor laundry room, along with two bedrooms on the main level. Upstairs, you'll find a private primary suite and an additional bedroom with its own en-suite bath, offering flexible living arrangements for family or guests. This home has been meticulously maintained with significant updates, including: 2019: Extensive main-floor renovation with floor plan modifications, new hallway, added laundry room, and a completely updated kitchen. 2021: Full exterior professionally sandblasted and stained. 2022: New roof and added skylights that fill the great room with natural light. 2024: New septic system drain field and lift station, plus new garage doors. 2025: Brand-new HVAC system. Whether you're sipping coffee on the porch, enjoying evenings by the stone fireplace, or taking in the peaceful surroundings, this one-of-a-kind log home offers the lifestyle you've been dreaming of. If you've been searching for timeless character, modern updates, and room to breathe, this extraordinary property is one you won't want to miss.

8 Whippoorwill Ct, Defiance
$625,000
4 Beds ⋅ 3 Baths ⋅ 26042478 MLS ⋅ ACTIVE Status
Embrace the serenity of this secluded 3-acre property at the end of a cul-de-sac, surrounded by trees and boasting not just one, but three separate buildings! The main 2-story home features Low Maintenance, Hail resistant Hardi Board Siding, offering possible lower insurance rates. Step inside to find a ceramic tile entry, coat closet, powder room, and a grand staircase with wood rails and wrought iron balusters. The spacious L-shaped great room showcases solid oak floors and a cozy wood stove, perfect for relaxing or entertaining. The custom Real Cherry cabinets in the kitchen are complemented by upgraded Austrian hardware for soft close drawers. Oversized Primary suite with sitting room/custom make-up area/nursery. 3 bedrooms have new carpet. The property doesn't stop there - a woodworking shop or she shed, barn, and pasture offer endless possibilities for hobbies or additional living space/possible Mother-in-law quarters. The woodworking/she shed building is constructed with 2 x 6 Stud construction and over-insulated walls. The building has heat and air conditioning. Enjoy the outdoors on the back patio or covered deck, overlooking the expansive backyard. Fruit trees, black raspberry bushes, and a vegetable garden add to the charm of this peaceful retreat. With freshly painted interiors, vinyl, triple-paned insulated windows, and a partially finished lower level with a second wood stove, newley installed upgraded laminate floor, this home is move-in ready. The oversized 2-car garage provides ample storage space and room for hobbies. Located near Busch Wildlife and Weldon Spring Conservation Area, this property offers a perfect blend of privacy and convenience. Create lasting memories in this beautiful oasis - schedule a showing today!

44 Wilderness Ln, Defiance
$364,950
3 Beds ⋅ 1 Baths ⋅ 26041787 MLS ⋅ ACTIVE Status
Ranch style, full brick home situated on 4.6 acres with an attached one car garage. The home has 3 bedrooms, 1 bath, 1296 square feet, some hardwood floors, and a full basement situated on a fairly level lot. Some photos are virtually staged.

3901 Hwy D, Defiance
$520,000
3 Beds ⋅ 2 Baths ⋅ 26037883 MLS ⋅ ACTIVE Status
Spacious ranch on 6 gorgeous acres conveniently located just minutes from wineries, schools, shopping and highways! This charming 3 bedroom, 2 bath home comes complete with main floor laundry, full, unfinished basement, and a primary bedroom with walk-in closet and ensuite bath. Besides the 2-car attached garage, there is a 28’x60’ insulated metal outbuilding with concrete floor, electric and 220 AC. Lots of deer and other wildlife on the wooded acreage. Some fresh paint and flooring will make this a rural oasis while still being just minutes to town conveniences. Being sold As-Is. Call Sherry for details. Interior pictures coming soon.

3877 Hwy D, Defiance
$749,900
4 Beds ⋅ 4 Baths ⋅ 26034897 MLS ⋅ ACTIVE Status
This spacious 4 bedroom 4 bath ranch home is beautifully situated on a 3 acre wooded lot creating a private, peaceful oasis which features a saltwater pool with waterfall, perfect for relaxing and entertaining. This remarkable home is located in the coveted Francis- Howell School District. The recently refinished wide-plank hardwood floors are simply outstanding. The first floor has a large office, half bath and laundry area for all of today's modern needs. A large living/family room with fireplace leads to an outdoor brick terrace. The family dining area with fireplace opens to a screened-in porch. The primary bedroom includes a walk in closet and an en-suite bathroom with vaulted ceiling and separate shower. The finished lower level, with wet-bar, includes plenty of built-in bookcases. The oversized three-car garage offers additional storage space.

2 Woodridge Dr, Defiance
$499,900
3 Beds ⋅ 3 Baths ⋅ 26026667 MLS ⋅ ACTIVE UNDER CONTRACT Status
Country living on 5.21+/- level STUNNING acres in unincorporated Defiance! A tree lined driveway leads to a CHARMING, RANCH home with 3 bedrooms, 2.5 baths & 1,978+/- SqFt of living space that offers an AWESOME, 30’ x 24’, 2-car, detached garage & shed. Partially covered front porch greets you as you step inside the entry foyer. Step down, living room boasts a floor-to-ceiling brick wood burning fireplace, 14’+/- vaulted ceiling w/wood beams & dry bar w/custom cabinetry. Breakfast room features wood railing overlooking the living room & sliding glass walk-out to patio allowing plenty of natural light. Eat-in kitchen offers custom cabinetry, white appliances, Formica “wood like” countertops & laminate “tile like” flooring. Primary suite with carpet & ensuite full bath with shower w/sliding glass doors, 2 single sink vanities (1 w/make alcove), walk-in closet & linen closet. Other 2 bedrooms with carpet, slide closets & share hall bath with shower/tub & single sink vanity. Dining room & laundry/half bathroom completes the main level. Unfinished lower-level has great potential for additional living space awaiting your finishing touches with 8’+/- ceiling. Within the Francis Howell School District & easy access to HWY DD & HWY F. MUST SEE!

2540 S Hwy 94, Defiance
$1,690,000
4 Beds ⋅ 4 Baths ⋅ 26029468 MLS ⋅ ACTIVE Status
Welcome home to this beautifully appointed brick ranch that truly has it all—inside and out. Situated on approximately 10+/- acres, this property offers the perfect blend of privacy, space, and resort-style living. Step into your own private backyard retreat featuring a stunning in-ground saltwater pool (9.5 ft deep), complete with heating and cooling for extended seasonal enjoyment. The surrounding patio provides ample space for entertaining, complemented by a large cedar deck, outdoor lighting, and a dedicated firepit area—perfect for relaxing evenings. A designated playground area adds even more versatility to the outdoor space. Inside, you’ll find an inviting open floor plan highlighted by a striking beamed ceiling and a spacious great room with a cozy wood-burning fireplace. The chef’s kitchen is a standout, showcasing custom cabinetry, under-cabinet lighting, a pot filler, expansive center island, and a stylish bar area with a built-in refrigerator—perfect for hosting. The luxurious primary suite is designed for comfort and relaxation, featuring a coffered ceiling, gas fireplace, dual closets, and a spa-like bath with dual vanities and a standalone soaking tub. Additional features include a potential home office, oversized garage, and a convenient main floor laundry room with sink and built-in cabinetry. The finished walk-out lower level significantly expands your living space, offering an additional bedroom, sleeping area, a full bath, spacious recreation room, and bar area—plus a storage room for added convenience. Step directly outside to the pool area, making this level ideal for entertaining and guest accommodations alike. This exceptional home combines high-end finishes, functional design, and incredible indoor-outdoor living on acreage—ready for you to enjoy.

4325 Hueffmeier Rd, Defiance
$649,900
4 Beds ⋅ 3 Baths ⋅ 26030764 MLS ⋅ ACTIVE Status
Nestled on 8+ scenic acres off coveted Matson Hill Road in Unincorporated St. Charles County, this meticulously maintained retreat offers the perfect blend of refined comfort and peaceful country living. Surrounded by mature trees, wildlife, and nature, this stunning property delivers privacy without sacrificing convenience. Welcoming foyer opens to formal living and dining rooms before leading to a breathtaking vaulted and beamed great room anchored by a wood-burning fireplace. Spacious country kitchen features custom wood cabinetry, Corian countertops, center island, double ovens, and breakfast area that opens to an expansive approx. 36’x20’ deck with tempered glass railing designed to maximize views of the surrounding woods and wildlife. Enjoy deer, turkey, birds, and a private wooded path leading to a wet-weather creek. Upper level offers 3 spacious bedrooms with hardwood flooring throughout. Luxurious owner’s suite includes walk-in closet and updated bath with marble tops, adult-height double vanities, and tiled shower. Finished walk-out lower level is ideal for multi-generational living or guest quarters with sleeping area, den, kitchenette, and full bath. Oversized side-entry garage offers RV hookup, generator hookup, workshop space, and abundant storage. Circular driveway welcomes guests while additional drive leads to pole barn with electric and lean-to for equipment, hobbies, workshop, or storage. Minutes from Matson Hill Park, the Katy Trail, wineries, and all the beauty Defiance area living has to offer.

800 Matson Hill Rd, Defiance
$2,375,000
3 Beds ⋅ 5 Baths ⋅ 26030057 MLS ⋅ ACTIVE Status
Experience the ultimate in privacy and natural beauty with this stunning custom waterfront property nestled on 25.5+/- mostly wooded acres with frontage on the serene waters of Callaway Valley Lake. Crafted with exceptional attention to detail, this one-of-a-kind property showcases rich woodwork and impeccable craftsmanship throughout. Highlighted by a grand wood-paneled ceiling with softly arched beams, and a floor to ceiling stone fireplace that lend warmth and architectural elegance to the main living space. At the heart of the home lies an open, elegant luxury kitchen that is sure to impress with custom cabinetry, premium appliances, and generous prep space, making it ideal for both everyday living and entertaining in style. Hop in the side by side and head to the lake to enjoy your own private boat dock, perfect for fishing, kayaking, sunset cruises, or simply soaking in the peaceful lakeside setting. This land is ideal for hunting, hiking, and exploring, offering year-round outdoor adventure in your own backyard. Additional features include a total of 7 garage spaces, a versatile detached 3 car garage, a large chicken coop, and charming Barn with loft space and concrete floors adding both functionality and character to this exceptional property. All of this is set within a peaceful, wooded landscape that feels worlds away—yet is just minutes from New Melle, Wentzville and Defiance, Missouri. ATTN: option to just purchase additional acreage available at 50k/acre.

353 Callaway Ridge 25.5 Dr, Defiance
$679,900
3 Beds ⋅ 3 Baths ⋅ 26024526 MLS ⋅ ACTIVE Status
Rarely does an opportunity like this come available in Defiance! Located in the beautiful Femme Osage valley, nestled on 9+ picturesque acres, this 3 bed, 2.5 home offers the perfect blend of privacy, space, and comfort. The setting is rural but convenient to highway 64/40, Chesterfield, Wentzville, and Francis Howell schools. Step inside to find hardwood floors throughout the main level, leading to a well appointed kitchen featuring granite countertops and stainless steel appliances. The main floor primary suite provides convenience and retreat with a private bath, while upstairs offers two spacious bedrooms and a full bath! The finished lower walk-out level adds additional living and entertaining space, complete with built-in shelving for your media set-up. One of the true highlights of the home is the stunning four seasons room with floor-to-ceiling windows and skylights, bringing in natural light and year round beautiful views of the surrounding area. Step outside to the expansive wrap-around deck–perfect for private enjoyment of the great view and star-gazing! With an attached 2-car garage and ample driveway parking, this property combines functionality with a truly beautiful setting you won’t want to miss! Granite countertops Stainless steel appliances Main floor primary suite Half bath in main floor hallway Expansive wrap-around deck Ample driveway parking Low Utilities Great schools

1451 Hwy F, Defiance
$650,000
3 Beds ⋅ 2 Baths ⋅ 26023819 MLS ⋅ ACTIVE Status
Custom built, beautifully crafted home with over 2,000 sq feet of living space with luxury finishes. Located on 5 unrestricted acres, mostly wooded, outside New Melle in the heart of wine country. Private and peacefully located with access to major roads, living in country with easy access to all modern conveniences. Stepping Inside you are greeted with soaring 10' ceilings, open floor plan from the foyer, great room, kitchen with Quartz countertops, large center Island, walk in pantry, and beverage center in dining area, perfect for entertaining. The primary suite offers a relaxing retreat, custom tiled walk-in showers, soaking tub, WIC. Other two bedrooms and full bath (it also has custom tile work) are located across the great room. The main floor has a laundry room with custom tile, built ins and walks out to the deep, oversized 3 car garage. Open staircase off the foyer opens to an unfinished walk out basement, full bath rough in, just waiting for your endless creativity to personalize it. Outside you will enjoy the natural stone landscaping and your private woods. Located in the Francis Howell School District. Must have confirmed appointment to show.

215 Rugged Acres, Defiance
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